Carolina Aguiar Moreira1,2,3
Carlos Eduardo dos S. Ferreira4,5,6
Miguel Madeira1,7
Barbara Campolina Carvalho Silva1,8,9
Sergio Setsuo Maeda1,10
Marcelo Cidade Batista4,5
Francisco Bandeira1,11
Victória Z. Cochenski Borba1,2
Marise Lazaretti-Castro1,10
1 Departamento de Metabolismo
Ósseo, Sociedade Brasileira
de Endocrinologia e
Metabologia (SBEM), Brasil
2 Serviço de Endocrinologia e
Metabologia do Hospital de Clínicas
da Universidade Federal do Paraná
(SEMPR), Curitiba, PR, Brasil
3 Laboratório PRO, Unidade de
Histomorfometria Óssea, Fundação
Pró-Renal, Curitiba, PR, Brasil
4 Sociedade Brasileira de
Patologia Clínica/Medicina
Laboratorial (SBPC/ML)
5 Medicina Diagnóstica
e Ambulatorial (MDA),
Departamento de Patologia
Clínica, Hospital Israelita Albert
Einstein, São Paulo, SP, Brasil
6 Disciplina de Medicina
Laboratorial, Laboratório Central,
Escola Paulista de Medicina,
Universidade Federal de São Paulo
(EPM-Unifesp), São Paulo, SP, Brasil
7 Unidade de Endocrinologia,
Universidade Federal do
Rio de Janeiro (UFRJ), Rio
de Janeiro, RJ, Brasil
8 Unidade de Endocrinologia,
Hospital Felício Rocho e Santa
Casa de Belo Horizonte, Belo
Horizonte, MG, Brasil
9 Disciplina de Endocrinologia,
Centro Universitário de Belo
Horizonte (UNI-BH), Belo
Horizonte, MG, Brasil
10 Disciplina de Endocrinologia,
Escola Paulista de Medicina,
Universidade Federal de São Paulo
(EPM-Unifesp), São Paulo, SP, Brasil
11 Divisão de Endocrinologia e
Diabetes, Faculdade de Medicina,
Universidade de Pernambuco
(UPE), Recife, PE, Brasil
ABSTRACT
Hypovitaminosis D is a common condition with a negative impact on health. This statement, prepared
by experts from the Brazilian Society of Endocrinology and Metabolism and the Brazilian Society
of Clinical Pathology/Laboratory Medicine, includes methodological aspects and limitations of the
measurement of 25-hydroxyvitamin D [25(OH)D] for identification of vitamin D status, and identifies
individuals at increased risk for deficiency of this vitamin in whom 25(OH)D measurement is
recommended. For the general population, 25(OH)D levels between 20 and 60 ng/mL are considered
normal, while individuals with levels below 20 ng/mL are considered to be vitamin D deficient.
This statement identifies potential benefits of maintaining 25(OH)D levels > 30 ng/mL in specific
conditions, including patients aged > 65 years or pregnant, those with recurrent falls, fragility
fractures, osteoporosis, secondary hyperparathyroidism, chronic kidney disease, or cancer, and
individuals using drugs with the potential to affect the vitamin D metabolism. This statement also
calls attention to the risk of vitamin D intoxication, a life-threatening condition that occurs at 25(OH)
D levels above 100 ng/mL. Arch Endocrinol Metab. 2020;64(4):462-78
Keywords
Vitamin D; 25-hydroxyvitamin D; reference range; vitamin D intoxication
https://www.aem-sbem.com/media/uploads/2019-0153_fiXqxfd.pdf