Chemotherapy for Advanced Non–Small-Cell Lung Cancer in Elderly Patients

oncol edit

Autores: Fábio Nasser Santos, MD; Marcelo Rocha Souza Cruz, MD; Rachel Riera, MD, MSC, PhD

JAMA Oncology Clinical Evidence Synopsis • Doi: 10.1001/jamaoncol.2016.2050 • December 2016


Clinical Question  Do patients above 70 years of age with newly diagnosed advanced non–small-cell lung cancer benefit from platinum-based combination or should they receive non-platinum agents either as single-agent or in combination?

Bottom Line  For fit elderly patients platinum-based combination is associated with better overall survival, progression-free survival, and objective response rate, however this improvement should be counter balanced against the higher risk of major adverse events (AE).

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