The Graduate Program in Otorhinolaryngology promotes the development of clinical studies associated with basic research. Thus, clinical trials that can assess the applicability of new diagnostic and therapeutic resources are as important as contributing to the generation of new basic knowledge.
2. Audiological, psychoacoustic and psychological aspects of patients with tinnitus
Despite tinnitus being a problem that affects a significant portion of the population, the diagnosis and treatment of tinnitus remains a challenge for health professionals. The influence of the degree of hearing loss on tinnitus severity is still uncertain. The way an individual cope with their disease is related to multiple factors such as disease severity, life history, habits, and especially personality. This study aims to deepen the knowledge of aspects associated with the onset, perception, maintenance, and discomfort of tinnitus. The aim of this study is to assess the presence, frequency, and intensity of tinnitus through audiometric tests and scales of tinnitus perception by the patient. Evaluate the sample's personality characteristics and psychic dynamics. Assess the presence of depressive and anxious symptoms. Investigate the presence of symptoms of obsessive-compulsive disorder. Assess the patient's adaptation to tinnitus and its discomfort in their life.
Coordinator: Profa. Dra. Norma de Oliveira Penido
3. Genetic aspects of nasosinusal disorders
Nasosinusal diseases have a multifactorial etiology, with an important participation of genetic factors. Changes in the genetic sequence, gene expression and its regulation can influence the genesis and development of the disease, as well as clinical evolution and response to treatment. Furthermore, several new technologies have been developed for the study of genomics and transcriptomics. The objective of this research project is to study the possible roles that genetic alterations can play in nasosinusal diseases.
Coordinator: Prof. Dr. Luis Carlos Gregorio
4. Assessment of vestibulocochlear changes in otitis media
Evaluate the sequence of lesions in the sensory epithelium of cochleovestibular structures in the various clinical presentations of middle ear infections and inflammatory processes through imaging studies of human temporal bones; Define appropriate therapeutic measures for each clinical presentation of otitis media.
Coordinator: Profa. Dra. Norma de Oliveira Penido
5. Assessment of body balance and quality of life in vestibular patients
This project addresses the study of various methods of assessing body balance, including postural, posturographic and functional balance assessments in patients with vestibular disorders and the impact of vestibular manifestations on the quality of life of patients with vestibular disorders.
Coordinator: Prof. Dr. Fernando Freitas Ganança
6. Evaluation of protein, cell and tissue components involved in the mechanical properties of nasal tissue
Evaluate the proteins involved in the composition of the extracellular matrix and those involved in cell junctions that interfere with the mechanical properties of the nasal mucosa. We evaluated the role of the main cells involved in the remodeling process and ways of interfering with the mechanical properties of the nasal mucosa. In these studies, we evaluated the mechanical dysfunction found in nasal polyposis by culturing and comparing stem cells and their main proteins using Elisa, Multiplex tests. Cultivation of fibroblasts and analysis of their tensile strength through the test of adherence and cell contraction stimuli. We worked on the evaluation of the extracellular matrix of the polyp and nasal mucosa, evaluating the properties of the effect of fibrosis in nasal polyposis through tissue compliance studies and interfering in the quality of the extracellular matrix through the crosslinking process using Ultraviolet B.
Coordinator: Prof. Dr. Rogerio Pezato
7. Structural assessment of the upper airways in sleep disorders
Sleep-disordered breathing (SDB) is of great importance in the clinical practice of otorhinolaryngology. Several changes in the general physical and otorhinolaryngological examinations have been associated with the presence of SDB. Objective: To perform a descriptive analysis of the characteristics of the cervico-orofacial physical examination, sleep and upper airway symptoms, and polysomnographic data.
Coordinator: Profa. Dra. Fernanda Louise Martinho Haddad
8. Multidisciplinary evaluation of mouth breathers
Study all (multidisciplinary) aspects related to mouth breathing syndrome, including etiology, epidemiology, treatment, and prevention. Evaluation of dental performance on facial growth and breathing.
Coordinator: Profa. Dra. Shirley Shizue Nagata Pignatari
9. Sensory and neural dysfunction of the VIII cranial nerve
Investigate hearing disorders through the evaluation of candidates capable of rehabilitation through implantable prostheses and the respective measurement of the results obtained with this new treatment modality. Other clinical treatments for diseases with progressive sensorineural hearing loss are also investigated.
Coordinator: Prof. Dr. Jose Ricardo Gurgel Testa
10. Facial nerve dysfunctionsl
Clinical and experimental study of the various aspects of peripheral facial paralysis and its implications for the quality of life of individuals with it. Evaluating clinical, etiological, epidemiological factors, as well as aspects of facial nerve degeneration and regeneration, in humans and guinea pigs.
Coordinator: Prof. Dr. Jose Ricardo Gurgel Testa
11. Osteomucous dysfunctions of the temporal bone
Identify the main findings through imaging exams (tomography and resonance) in osteodystrophies and evaluate the usefulness of these exams as a diagnostic method and therapeutic indicator of this osteodystrophy, as well as evaluating the therapeutic effectiveness with the use of medications (Alendronate and Fluoride). Multicenter prospective study.
Coordinator: Profa. Dra. Norma de Oliveira Penido
12. Laryngeal mobility disorders in neurological disorders: diagnosis and treatment
The development of specialized tools for diagnosis, prognosis and treatment, such as protocols and tests, which can contribute to the assessment and monitoring of patients with neurological disorders that affect laryngeal function and can be incorporated into clinical practice is the main purpose of the project. Equipment: Nasofibrolaryngoscope, stroboscopy device, light source, Nihon Kohden Electromyograph, two channels, computer, unidirectional microphone.
Coordinator: Profa. Dra. Noemi Grigoletto de Biase
13. Sleep disorders
Our objective is to investigate the alterations related to primary snoring, upper airway resistance syndrome and obstructive sleep apnea. We emphasize the investigation of possible causes (obstructive or functional), test diagnostic tools, assess sequelae, repercussions and experiment with new methods of clinical, surgical and rehabilitation treatment. For this, the work team is made up of professionals from various sectors and disciplines, including otolaryngologists, clinicians, sleep professionals, psychologists, among others. Equipment: Tele-Nasofibroscope, Polysomnography (Sleep Laboratory), Software and specific programs for cognitive assessment (learning, memory, attention), Acoustic rhinomanometry, Specific surgical material.
Coordinator: Profa. Dra. Fernanda Louise Martinho Haddad
14. Effects of treatment of upper aerodigestive tract neoplasms
The aim of the project is to identify, quantify, mitigate, and rehabilitate the consequences of treatment, whether surgical, chemotherapy or radiotherapy in patients with epithelial neoplasms of the upper aerodigestive tract.
Coordinator: Prof. Dr. Onivaldo Cervantes
15. Swallowing Study
Pharyngolaryngeal swallowing alterations are very prevalent in our country. It is estimated that more than 90% of the population develops some degree of dysphagia as the population ages. Despite this, this entity can affect all age groups (from premature children to the elderly or super elderly) and can result from neurological, muscular and autoimmune diseases and local factors. The importance of its understanding and management lies in the fact that many of these patients evolve with aspiration pneumonia, which can culminate in a lethal outcome. At this time of pandemic and increase in individuals in intensive care, there was also a great increase in these cases. Dysphagia, which is the disorder of swallowing function, can impact the nutrition of individuals and the aspiration of food or saliva in lower respiratory tract infections, generating life-threatening consequences.
Coordinator: Profa. Dra. Noemi Grigoletto De Biase
16. Voice Study
Vocal alterations are very prevalent in our country. It is estimated that more than 70% of the population uses the voice as a work tool. Changes in the vocal tract may lead to hoarseness and consequent impairment in daily and work activities. Therefore, directly impacting the country's economic activity. Such changes can affect all age groups (from children to the elderly). Among the possible etiologies, it can be identified from simple vocal adjustment alterations to congenital lesions, benign lesions caused by phonotrauma, neurological diseases and even laryngeal tumors. At this time of pandemic and increase in individuals in intensive care, laryngeal alterations with repercussions on both the voice and breathing of affected individuals have become more prevalent. Voice disorders significantly interfere with patients' self-esteem and their ability to communicate.
Coordinator: Profa. Dra. Noemi Grigoletto De Biase
17. Auditory and para-auditory factors in tinnitus pathophysiology and/or intolerance to sounds
It studies the participation of the various factors involved in tinnitus pathophysiology and/or intolerance to sounds (sensory and neural structures of the peripheral and central auditory pathways, stomatognathic system, psychological, etc.) through auditory assessments, psychoacoustic characteristics of tinnitus, electrophysiological tests, and diagnostic imaging exams (computed tomography, SPECT, magnetic resonance). Assessment of the impact of tinnitus on daily activities through questionnaires and scales.
Coordinator: Prof. Dr. Ektor Tsuneo Onishi
18. Inflammatory markers and disorders of the upper respiratory digestive mucosa
Clinical and laboratory studies, studying the immune, inflammatory, and oxidative stress responses, comparing systemic responses with the airway response and molecular biology in order to elucidate pathophysiological mechanisms and enhance therapeutic approaches in inflammatory diseases of the upper respiratory digestive mucosa, as well as the study of parameters mentioned above in amateur athletes submitted to exhaustive efforts.
Coordinator: Prof. Dr. Mauro Walter Vaisberg
20. Pathophysiological mechanisms of changes in craniofacial growth and rehabilitation of facial deformities
The objective is to identify the multiple pathophysiological processes responsible for changes in craniofacial growth and use diagnostic imaging resources associated with specific software programs that provide us with overlapping anatomical structures and 3D reconstruction, in addition to volumetrically measuring structures such as nasal airspace, maxillary sinuses, oropharynx and nasopharynx to correct facial growth deviation and identify the best therapeutic and oral orthopedic strategies for rehabilitation of functions: respiratory, masticatory and phonatory.
Coordinator: Prof. Dr. Mario Cappellette Junior
22. Pathophysiological mechanisms, diagnostic methods, and treatment of thyroid gland disorders
Study the pathophysiological mechanisms involved in the development of diseases and the diagnostic methods and treatment of benign and malignant conditions of the thyroid gland.
Coordinator: Prof. Dr. Onivaldo Cervantes
23. Nose and paranasal cavities in respiratory disorders
Breathing is one of the primary functions of the nose and its perception by the patient can be influenced by several anatomical and functional factors. The assessment of breathing involves subjective and objective aspects, and we currently have several techniques for measuring it. The aim of this research project is to evaluate the impact of the nose and paranasal cavities on respiratory disorders using the various tools available, such as rhinometry, rhinomanometry, peak nasal inspiratory flow and imaging tests. Evaluation of CPAP in the diseased upper airways.
Coordinator: Prof. Dr. Luis Carlos Gregorio
24. New approaches to inflammatory sinonasal diseases
Sinonasal inflammatory conditions affect a large portion of the population and cause significant repercussions on the quality of life of these patients. There are inherent difficulties in diagnosis and treatment that need to be addressed, due to the wide spectrum of presentations related to rhinitis and rhinosinusitis, in addition to the need to customize therapy to optimize the result. The objective of this research project is to study the possible pathophysiological mechanisms and new diagnostic and therapeutic approaches for sinonasal inflammatory disorders.
Coordinator: Prof. Dr. Eduardo Macoto Kosugi
25. New therapeutic approaches to epistaxis
The treatment of severe epistaxis is always challenging, with considerable failure rates in clinical treatment, in addition to the difficulty inherent in surgical procedures. The purpose of this research project is to investigate new technologies, clinical protocols, and techniques for the treatment of this condition.
Coordinator: Prof. Dr. Eduardo Macoto Kosugi
26. New radiological tools in childhood obstructive sleep apnea syndrome
Use of new computer programs and the Dental Scan tool in orthodontic imaging exams with cephalometric measurements, anthropometry, symptoms, and signs for the measurement of upper airways in childhood and creation of objective clinical parameters in the diagnosis of oral breathers, primary snorers and apneic patients.
Coordinator: Prof. Dr. Reginaldo Raimundo Fujita
28. Sensorineural hearing loss
Sensorineural hearing loss is a symptom that promotes disabling deficits whose diagnosis and evolution remain a major challenge. It is proposed to research the etiology through clinical, imaging and laboratory exams, as well as to monitor the auditory evolution and possible factors that interfere in the recovery of auditory thresholds after treatment with corticosteroids.
Coordinator: Profa. Dra. Norma de Oliveira Penido
30. Polysomnography in sleep disorders
Analysis and evaluation of polysomnographic examination in adult individuals to assess normality patterns and their alterations. It aims to correlate clinical symptoms, physical examination findings with polysomnographic findings, normal sleep, and sleep disorders.
Coordinator: Prof. Dr. Luis Carlos Gregorio
31. Prevention of judicialization and assessment of the main complaints against Medicine
Evaluation of complaints and inquiries against doctors; Search for mechanisms that can protect medical practice and provide prophylaxis against lawsuits in the practice of Medicine; Evaluation of informed consent terms and their values; Role of the technical assistant in proceedings against doctors (civil sphere).
Coordinator: Prof. Dr. Reginaldo Raimundo Fujita
32. Implantable prostheses and orthotics in the temporal bone
Sensorineural hearing loss has proved to be a great challenge for otology in the 21st century. As the sensory cells of the cochlea, responsible for the acoustic-electrical transduction, have no regenerative capacity, the rehabilitation of their loss can be achieved with acoustic amplification, in partial injuries, or electrical stimulation in severe or total injuries. In this field, implantable prostheses can be a therapeutic option in several cases. There is already available implantable equipment for acoustic stimulation of the remaining sensory cells and equipment capable of electrical stimulation of the central auditory pathways. This line of research is aimed at standardizing the indications of these equipment, evaluating the results obtained, and researching the results obtained. These data will allow, in addition to the analysis of medical aspects, the improvement of surgical techniques and electronic training of devices.
Coordinator: Prof. Dr. Oswaldo Laercio Mendonça Cruz
33. Rehabilitation of body balance
This project includes the study of the various procedures involved in the treatment of acute or chronic, peripheral, or central vestibular disorders, through the stimulation of the vestibular, visual and proprioceptive systems, using specific physical exercise programs with and without the aid of electronic devices, on the ground or in the aquatic environment, of virtual reality and/or electro-tactile stimulation of the tongue.
Coordinator: Prof. Dr. Fernando Freitas Ganança
34. Rehabilitation of patients with tinnitus and/or sound intolerance
Evaluate drug and non-drug therapeutic possibilities, therapy techniques (sound, sound generators, habituation, biofeedback, mindfulness) and the applicability of Traditional Chinese Medicine (acupuncture, electroacupuncture, moxatherapy, herbal medicine) in patients with tinnitus unresponsive to conventional drug treatment.
Coordinator: Prof. Dr. Ektor Tsuneo Onishi
35. Rehabilitation of deficits caused by deafness and dizziness
It studies the indications and effectiveness of methods for the rehabilitation of sensorineural hearing loss and body balance disorders of vestibular origin. Use of implantable prostheses and orthoses in the temporal bone that enable hearing rehabilitation. Study of the various procedures involved in the treatment of acute or chronic, peripheral, or central vestibular disorders, through stimulation of the vestibular, visual, and proprioceptive systems, using specific physical exercise programs with and without the aid of electronic devices, on the ground or in the aquatic environment, of virtual reality.
Coordinator: Prof. Dr. Fernando Freitas Ganança
37. Results of different types of treatment for sleep-disordered breathing
Evaluate the results of the different treatments (clinical and surgical) of sleep-disordered breathing, with special attention to craniofacial dysmorphisms and alterations in the upper airway in patients with Obstructive Sleep Apnea Syndrome (OSAS).
Coordinator: Prof. Dr. Luis Carlos Gregorio
38. Sphenoid sinus and its relationship with the septa and internal carotid artery in computed tomography
The sphenoid sinuses have septa that can be a confounding factor when performing transsphenoid surgery, as they have great variability in position and conformation. There is also frequent and underestimated proximity of these septa with the ICA, reaching direct insertion in the parasellar and/or paraclival carotid prominences in 87% of cases, which can lead to operative complications if this fact is neglected. The aim of the study is to evaluate the development of the sphenoid sinus at different ages and to evaluate the characteristics of the septa of the sphenoid sinuses, demonstrating their relationship with the internal carotid artery in 50 CT scans with thin slices of the skull base performed at Hospital São Paulo.
Coordinator: Profa. Dra. Shirley Shizue Nagata Pignatari
39. Syndrome of sudden sensory loss of smell (or anosmia), taste (or dysgeusia) and hearing (dysacusis) in patients infected with the sars-cov-2 coronavirus
To investigate the relationship between the presence of the virus in the upper airways and changes in the mucosal immune response of the airways and systemic that can lead to total or partial loss of smell, taste, and hearing.
Coordinator: Profa. Dra. Norma de Oliveira Penido
Update: July 27, 2022