Escola Paulista de Medicina
Postgraduate Program in Urology

Post-translational modifications of seminal proteins and their importance in male fertility potential.

Pag 9


Maciel VL Jr, Tamashiro LK, Bertolla RP.




Introduction: The seminal proteome has been shown to directly influence the male fertile potential. Post-translational modifications (PTMs) are significant changes that play a role in the biological regulation of proteins. Sperm cells are transcriptionally and translationally inactive and these modifications are essential to control protein function. Areas covered: Here we reviewed seven PTMs which importance for male reproductive function investigated in the past decade, namely S-nitrosylation and tyrosine nitration (both occurring by the action of NO), glycosylation, ubiquitination, acetylation, methylation, and SUMOylation. Since they were previously identified in human semen, we focus on their role in sperm function, as well as in physiological and pathophysiological processes which could contribute to the fertility potential. The following keywords were applied: 'post-translational modification', 'sperm', 'semen', 'seminal plasma', 'male infertility', 'nitrosylation', 'nitration', 'histone methylation', 'SUMOylation', 'ubiquitination', 'ubiquitilation', 'glycosylation', and 'acetylation'. Expert opinion: Most biological processes orchestrated by proteins require PTMs for their activation or inhibition. Most of them are dynamic and occur in mature sperm, modulating protein function, thus exerting a significant role in sperm function and fertility. Finally, the study of PTMs should be also addressed in pathophysiological processes, as different clinical conditions are known to alter the proteome.

DOI: 10.1080/14789450.2019

Artigos Relacionados - Artigos Científicos

02 Mar 2020 17:05


de Lima Santos A, Silva CGD, de Sá Barretto LS, Franciozi CEDS, Tamaoki MJS, de Almeida [ ... ]

Artigos Cientificos
01 Mar 2020 21:22


Braga DPAF, Borges E Jr, Godoy AT, Montani DA, Setti AS, Zanetti BF, Figueira RCS, Eberlin [ ... ]

Artigos Cientificos
02 Mar 2020 21:22


Camargo M, Intasqui P, Belardin LB, Antoniassi MP, Cardozo KHM, Carvalho VM, Fraietta R, Bertolla [ ... ]

Artigos Cientificos

© 2013 - 2017 Escola Paulista de Medicina - Universidade Federal de São Paulo - Unifesp

Rua Napoleão de Barros, 715, 2º andar - Vila Clementino São Paulo - SP • CEP 04024-002
+55 11 5576 4848 VoIP 4086  •