Autores: Fábio Nasser Santos, MD; Marcelo Rocha Souza Cruz, MD; Rachel Riera, MD, MSC, PhD
Clinical Question Do patients above 70 years of age with newly diagnosed advanced non–small-cell lung cancer benefit from platinum-based combination or should they receive non-platinum agents either as single-agent or in combination?
Bottom Line For fit elderly patients platinum-based combination is associated with better overall survival, progression-free survival, and objective response rate, however this improvement should be counter balanced against the higher risk of major adverse events (AE).